Expression Profiling of the Tripartite Motif Family Genes in Chronic Hepatitis C Patients

Hepatitis C virus (HCV) is one of the most prevalent pathogens which causes significant morbidity and mortality in 2% world’s population. Several interferon-stimulated genes (ISGs) are involved HCV clearance by interacting with viral proteins. Among these ISGs, tripartite motif (TRIM) family elevated during infection. This study aims to evaluate expression three TRIM chronic hepatitis patients, distributed among different groups, including TRIM11, TRIM14, TRIM25. A total 242 participants were recruited this study, 182 infected 37 naïve individuals, 23 control individuals. Out 100 achieved sustained virologic response (SVR), 61 rapid (RVR), 21 patients developed hepatocellular carcinoma (HCC), showing no given treatments. Our results indicate highest levels mRNA transcripts RVR group increase 7.5 folds TRIM25, 6.68 followed data from SVR group. The elevation was also evident other i.e., HCC, patterns all genes. In addition levels, a linear correlation observed between mRNAs loads HCV. These showed potential role restriction.